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5 Natural Alternatives to Spironolactone for Acne

Various treatments exist to tackle acne. One of the most popular is spironolactone. While spironolactone has its merits, like every other medication, it's not one-size-fits-all. The drug has its roots in treating high blood pressure but has also been used off-label to treat hormonal acne, especially in women.

However, there are concerns about side effects like low blood pressure, heart problems, and potassium levels. Considering these, it's worth exploring alternatives to spironolactone for acne that are effective and natural.

Also read: How to choose the best acne treatment

Biggest Take-Aways:

  • Spironolactone, originally a diuretic, is often prescribed for treating hormonal acne but has various side effects.
  • Various alternative treatments are available for managing different types of acne, including hormonal acne.
  • Combining treatments, like spironolactone and certain birth control pills, can offer a more comprehensive approach to acne management.
  • Exposed Skin Care provides a holistic treatment solution that controls acne and contributes to overall skin health.

Hand wearing surgical glove holding red pill

The Rise of Spironolactone in Acne Treatment

Spironolactone has traditionally been used to treat high blood pressure. However, its androgen-blocking capabilities have led it to be used off-label to treat hormonal acne, particularly in women. It has seen varying degrees of success as an oral medication, especially in treating acne around the jawline, where hormonal fluctuations often trigger acne flares.

Spironolactone blocks androgen receptors, subsequently reducing oil production and acne vulgaris. However, like many other medications, spironolactone comes with its own baggage of side effects, including but not limited to breast tenderness, hormonal imbalances, and issues with potassium levels.

Many patients with acne may prefer a non-antibiotic treatment that does not involve the risk of side effects like spironolactone. Plus, some individuals are trying to become pregnant, so taking this medication may not be advisable.

Top 5 Natural Alternatives to Spironolactone for Acne

Each of these alternatives has unique advantages, targeting different aspects of acne, such as sebum production, hormonal imbalances, and inflammation.

Tea Tree Oil

When it comes to topical acne treatments, Tea Tree Oil stands out as a commendable alternative to spironolactone. Originally used by the indigenous peoples of Australia, this natural remedy has antiseptic and anti-inflammatory properties that effectively treat various skin conditions, including acne vulgaris.

How Does It Work?

  • Anti-Inflammatory: Reduces redness and inflammation associated with acne.
  • Antibacterial: Kills bacteria that may contribute to acne formation.
  • Sebum Control: Helps regulate oil production on the skin's surface.

Dropper of tea tree oil

Green Tea Extract

Green tea is more than just a comforting brew. It has bioactive compounds like catechins that have shown promise as a treatment for acne. As a topical treatment or supplement, green tea extract can be an effective natural alternative to spironolactone.

The Benefits Include:

  • Antioxidant Properties: Helps neutralize free radicals contributing to skin aging and acne.
  • Anti-Androgenic: Blocks androgen receptors much like spironolactone, but without the side effects.
  • Hormonal Balance: This may help in regulating hormonal fluctuations that cause acne.


Turmeric, a staple in many kitchens, has curcumin, which holds powerful anti-inflammatory and antioxidant properties. As an alternative to spironolactone, turmeric offers a multi-faceted approach to treating acne.

Why Consider Turmeric?

  • Anti-Inflammatory: Effectively reduces the inflammation associated with cystic acne.
  • Antibacterial: Kills bacteria and removes impurities from the skin.
  • Regulates Sebum: Helps control oil production to prevent future acne cases.

Hands holding turmeric root crops

Zinc Supplements

Zinc isn’t just for boosting your immune system; it’s also beneficial for your skin. Various studies have shown that zinc can reduce acne, especially when used as a topical treatment or an oral supplement.

Advantages of Zinc:

  • Anti-Inflammatory: Reduces the redness and irritation caused by severe acne.
  • Sebum Reduction: Helps in regulating the production of skin oil.
  • Accelerates Healing: Speeds up the body’s natural process of wound healing, reducing the lifespan of acne.

Evening Primrose Oil

Often overlooked, Evening Primrose Oil is rich in essential fatty acids that can be beneficial in treating hormonal acne. This oil is a good alternative to spironolactone as it offers a more natural approach to tackling acne.

Attributes Worth Noting:

  • Omega-6 Fatty Acids: Helps with skin repair and hydration.
  • Hormonal Regulation: Acts as a balancing agent for hormones, making it effective for acne in women.
  • Reduced Inflammation: Lowers the inflammatory response, thereby reducing acne outbreaks.

    Why Choose Exposed Skin Care for Managing Acne

    If you're wary of using spironolactone for acne, you might want to consider Exposed Skin Care. This comprehensive skincare system offers a powerful yet gentle alternative for managing various types of acne, from adult acne to moderate to severe acne.
    Exposed Skin Care Ultimate Kit

    Benefits of using Exposed Skin Care include:

    • No Harsh Side Effects: Unlike the potential side effects of spironolactone, Exposed Skin Care focuses on natural extracts that are gentle on the skin.
    • Holistic Treatment: Exposed Skin Care provides a full suite of products that work in tandem to clear acne.
    • Effective for Various Acne Types: Whether you're dealing with hormonal acne influenced by testosterone and male hormones or acne associated with conditions like PCOS, Exposed Skin Care offers targeted solutions.
    • Promotes Overall Skin Health: While medications like spironolactone may improve acne, they often do little for overall skin vitality. Exposed Skin Care goes beyond treating symptoms, contributing to a healthier skin texture and reduced scarring.

    So, if you've been taking spironolactone for acne and haven't seen your desired results, or if you're concerned about the long-term effects of spironolactone, Exposed Skin Care might be the right treatment for you.


    Many healthcare professionals often recommend spironolactone for managing acne. Yet, since spironolactone is a diuretic and often prescribed as a blood pressure medication, it has many side effects that may not appeal to everyone. This makes the search for alternatives even more pertinent.

    There's a broader conversation to be had about the kinds of treatments available for acne. While oral spironolactone for acne has been treated as an effective treatment, it's important to note that various approaches exist to manage this condition.

    Some individuals have been successfully treated with spironolactone, but it is not a one-size-fits-all solution. This brings us to holistic skincare solutions like Exposed Skin Care. Exposed Skin Care offers a range of products designed to control acne and promote overall skin health. 

    So, whether you are taking medication like spironolactone to treat acne or considering different treatments, know that the landscape is broad. The key is to find a regimen that works for you, addresses your specific skin issues, and fits your lifestyle.


    Is spironolactone a diuretic?

    Yes, spironolactone is used for treating conditions like high blood pressure.

    Is spironolactone effective for treating acne?

    Yes, spironolactone is an effective treatment for hormonal acne and is often prescribed for this purpose.

    What are the side effects of using spironolactone?

    Side effects can include fluid retention, lower blood pressure, and hormonal imbalances.

    Can spironolactone be used along with other treatments like birth control?

    Yes, spironolactone can be used alongside certain birth control pills to control acne.

    What are the benefits of Exposed Skin Care?

    Exposed Skin Care offers a holistic approach to treating acne, focusing on both clearing acne and promoting overall skin health.